They don't seem to be temperature sensitive but I know they are much more UV light sensitive so, provided they are kept in the dark, I don't worry about mine
Nonetheless, the European Crohns and Colitis Organisation released a consensus statement to support the use of thiopurines as a monotherapy or an adjunct to infliximab in CD and steroid-dependent UC, noting that thiopurines were significantly more effective than aminosalicylates in curbing flares of UC ( Thiopurines are also commonly used as adjunct therapy in a step-down strategy for treating severe CD
A smoother and gentler skin
For shortterm use (days to weeks), refrigeration at ~4C (39F) is generally acceptable
Denmark is an example of this ( Reference Laurberg, Cerqueira and Ovesen 11 , Reference Zimmermann and Boelaert 25 )
Because metformin on its own carries very little hypoglycemia risk, this pairing rarely calls for any change to your existing metformin dose